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CBD + Melatonin Supplement – Natural Formula to Promote Sleep & Relaxation

CBD and melatonin are natural substances that have long been recognised for re-establishing restorative sleep and promoting relaxation. Now for the first time, SuperSmart is combining them in an exceptional formulation available to buy in vegetarian capsules, probably the best alternative to sleeping tablets for re-establishing restorative sleep naturally and durably.

Who is CBD + Melatonin aimed at?

This highly innovative formulation is for anyone affected by the following:

  • Repeated problems with falling asleep at conventional times.
  • Difficulty getting up in the morning.
  • Waking frequently in the night.
  • Waking up too early in the morning.
  • Feeling tired on waking.
  • Feeling anxious about going to bed.
  • Chronic lack of sleep that impacts on daily life.
  • Insomnia.
  • Muscle or joint pain on waking or at bedtime.
  • Jet lag.

It is suitable for men and women of all ages. It’s particularly good for anyone with an unhealthy lifestyle, or who spends too much time in front of a screen, who works in an office or who has low levels of physical activity.

Why melatonin?

Melatonin is a hormone derived from serotonin, which is secreted by the pineal gland, primarily during the hours of darkness. Often referred to as the ‘sleep hormone’, it is crucial for regulating our circadian rhythms, particularly the sleep/wake cycle. It signals to the body where it is in the day/night cycle and promotes sleepiness at appropriate times.

Unfortunately, production of this hormone is nowadays significantly impaired by artificial light. At the end of the day, when the retina senses the decrease in light levels, a neural signal is sent to stimulate the production of melatonin and the start of the sleep process. Exposure to artificial light during these key hours thus has a deeply negative effect: melatonin secretion falls dramatically, only to resume later, causing an untimely peak in its production which results in fatigue and sleepiness in the morning (1). This is exacerbated by exposure to the blue light emitted by screens.

Melatonin production also declines with age, due to calcification of the pineal gland (2) and decreased melatonin receptor sensitivity. Indeed, studies have shown that after the age of 60, the deep and REM (or paradoxical) phases of sleep decline sharply and night-time waking increases.

Taking an external source of melatonin before bed is a recognised natural solution to correcting impaired melatonin secretion. Its effects have been demonstrated in people with and without sleep problems (3-4). Unlike drugs, it works without disrupting the different stages of sleep and causes no residual effects the following morning.

Various studies show that to obtain maximum efficacy, you need to take melatonin for a minimum of 3-4 days. However, use of this hormone at low doses (as is the case here) should not be prolonged indefinitely, 4 weeks at most, by which time things will be back to normal.

Does it produce any side-effects?

No particular adverse side-effects have been demonstrated in oral supplementation toxicology studies using a wide range of doses (from 1 to 300mg) over moderate treatment periods (5).

Why add CBD?

CBD does not induce sleep per se, but it helps promote relaxation, vasodilation and pain relief. It is a phytocannabinoid molecule found in hemp (Cannabis sativa) along with the well-known psychotropic substance tetrahydrocannabinol (THC). But unlike THC, CBD has no psychoactive effect – it will not get you ‘high’.

CBD is very similar to the endocannabinoid messengers produced by the body to trigger various responses (pain modulation (6-7), reduction in spontaneous locomotion (8-9), relaxation, hypothermia… (10)). Such is its similarity, it is (to varying degrees) able to bind to the same receptors and trigger the same sort of chain reactions. These receptors are primarily found on cell surfaces in the brain, central nervous system and immune system tissues.

What are the main elements of the chain reaction triggered?

  • Reduction in the inflammatory response (pain relief) (11-13).
  • Triggering of vasodilation (14).
  • Decreased intensity and impact of symptoms associated with anxiety or chronic stress (15-16) (with stress being a common cause of sleep problems).
  • Effect on other brain receptors, particularly serotonin, a neurotransmitter that controls mood and sleep.
  • Reduction in reactive oxygen species (ROS) and lipid peroxidation (17).

It’s an important element of the formulation as a lack of sleep is very often linked to stress.

How is CBD produced?

The CBD in this formulation is extracted from the leaves of Cannabis sativa, using supercritical carbon dioxide (sCO₂). This is an alternative mode of extraction to the organochlorine solvents normally used in such processes, but which are potentially harmful to the environment. Very eco-friendly, sCO₂ both ensures the final product is free from solvent residues and helps maintain the chemical integrity of the heat-sensitive molecules. It is odourless, colourless, non-toxic and non-inflammable and is completely safe for our health and our environment.

Are there any side-effects?

CBD is very different from THC, the psychoactive substance found in the same plant. It has an excellent safety profile in humans and is in no way associated with the public health problems posed by cannabis. Its half-life is around nine hours, after which it is excreted in urine in a metabolised form.

Five good reasons to take CBD + Melatonin

  1. CBD perfectly complements the effects of melatonin: one deals with the hormonal disruption caused by environmental factors, while the other tackles anxiety and stress, which are recognised factors in insomnia.
  2. Scientific studies show that melatonin’s mechanism of action is radically different from that of benzodiazepines. Unlike sleeping pills which enforce drowsiness and disrupt cognitive performance and the architecture of sleep, melatonin induces a form of ‘calm sleep’ (18-19).
  3. Western populations generally get less sleep than they need to stay on top form (20).
  4. Good quality sleep is essential for long-term health, as it has an effect on cognitive faculties, rebuilding damaged cells, neural synapse plasticity, the immune defences, tissue repair, efficacy of endogenous antioxidants, mental health, and maintenance of muscle and bone tissue.
  5. CBD and melatonin offer numerous other health benefits, particularly antioxidant, immune-stimulant and anti-inflammatory effects.

Additional steps for enhancing the efficacy of CBD + Melatonin

To maximise the effects of supplementing with this formulation, you can also follow the steps below:

1) Try to maintain a healthy lifestyle, particularly by avoiding frequent changes to your sleep habits, smoking, excess alcohol consumption, and using electronic devices in bed (mobile phones, tablets, computers …) Instead, establish a calm routine before you go to sleep – listen to soothing music, read, practise yoga or do breathing exercises, for example.

2) Restrict intense visual, physical auditory or mental stimulation in the two hours before bed.

3) Eat dinner at least two hours before you go to bed, and prioritise foods high in tryptophan, an amino acid involved in the production of melatonin and which encourages drowsiness. Good sources are seeds, wholegrain rice, dairy products, eggs, pulses, chocolate and brewer’s yeast.

In addition, light therapy can be valuable, potentially boosting the effects of melatonin, especially in people who spend a lot of time indoors.

One capsule taken 30 minutes before bed is generally enough to obtain this supplement’s benefits. It’s worth noting that melatonin receptors are usually more sensitive between the hours of 7pm and 8pm (21).

This expertly-dosed formulation is not designed to replace the many plant-based combinations already available (such as the highly-effective Advanced Sleep Formula); it does, however, offer a more powerful alternative if you take into account the impact stress and pain can have on sleep problems.

Precautions: Do not exceed the recommended dose. This product should not be used as a substitute for a varied, balanced diet. Keep out of children’s reach. Protect from light, heat and humidity. Not recommended for women who are pregnant or breastfeeding, or for those suffering from mental disorders or auto-immune diseases. Consult a health professional before taking this product if you have any health problems. Do not take melatonin before driving or using machinery.

Written: October 2018.

Buy CBD + Melatonin capsules to restore sleep.

Looking for a supplement to improve sleep quality? CBD + Melatonin are natural substances that promote physical and mental relaxation and helps to reduce the time it takes to fall asleep.

Melatonin and Weed: What Happens When You Mix Them

The exact relationship between cannabis and melatonin is yet to be fully understood by science, which prevents us from forming any definitive conclusions.

There are several aspects to cover, and the most important ones are:

  • Does cannabis influence melatonin levels?
  • Does cannabis interact with melatonin supplementation?

Before we get into their convoluted relation, we should first spend some time getting acquainted with melatonin.

Most people know that it’s an over-the-counter supplement that helps us fall asleep, but melatonin is actually a truly fascinating molecule.

An introduction to melatonin

Melatonin is a naturally occurring body-produced hormone, and its main function is to regulate the circadian rhythm (also known as the sleep-wake cycle).

The circadian rhythm is a natural biological internal process that repeats itself approximately every 24 hours.

This rhythm is observed in plants, fungi, animals and humans, and is driven by the circadian clock.

The circadian clock (also known as the circadian oscillator) is an evolutionary internally-synchronized mechanism which allows an organism to predict environmental changes, and accordingly fine-tune its biological responses.

This graphic helps clarify the numerous internal mechanisms of the circadian clock.

The main role of melatonin is to prepare the body for sleep, and this effect is achieved through several interlocking mechanisms.

Firstly, the retina (which is the light-sensitive layer of the eye) sends electrical impulses to the SCN (suprachiasmatic nucleus), a miniscule region within the brain.

The SCN receives the “brightness” data from the retina, and depending how “bright or dark” the data, sends new electrical impulses to the pineal gland, which is responsible for the secretion of melatonin.

The cooperation of these three systems (retina, SCN and the pineal gland) is how the human body produces melatonin, and it is completely intertwined with the circadian rhythm.

Melatonin production begins when night starts (courtesy of darkness), and stops when the day begins (courtesy of light), preparing the body to be awake.

Now we should check out the available research on melatonin and cannabis.

Melatonin and cannabis

While the effects of cannabis on sleep are well known (and undeniably complicated as they depend on numerous factors including type of weed, quantity, frequency of use, time of consumption and so forth), the relationship between cannabis and melatonin is severely unresearched.

Rare mentions of melatonin in regards to cannabis come from a 2017 study (1) from the Oregon Institute of Occupational Health Sciences.

In it, the research team states:

Cannabis alters the sleep–wake cycle, increases the production of melatonin, and can inhibit the arousal system by activating cannabinoid type 1 (CB1) receptors in the basal forebrain and other wake-promoting centers.”

The aforementioned study was also quoting an older research from 1986 (2), which was observing melatonin levels in nine male volunteers (ages 29 to 33), after consuming a joint containing THC, and a regular cigarette without any THC.

This research found that after using cannabis, eight out of nine participants had a significant increase of melatonin in the blood.

Two additional aspects that the scientists also cited are frequency of use, and quantity of consumed cannabis.

According to their analysis, THC lessens the time required to fall asleep in occasional users, but also in frequent users (only in low doses).

High doses of THC in frequent users can cause increased sleep latency (more time required to fall asleep), shorter duration of sleep, and less slow-wave sleep (also known as the “deep sleep” phase).

What happens when you mix melatonin and weed?

Before we get into this paragraph, it’s important to note that no research was performed on the combined effects of cannabis and melatonin, and therefore we don’t condone or advise the use of these substances in unison.

The advised dose for melatonin is between 1 and 3 milligrams, and it’s also recommended not to consume melatonin supplements for a period longer than two months.

It’s also relevant to mention that since both melatonin and cannabis are safe substances, combining them infrequently and responsibly should not bring about any serious adverse effects.

The main sensations from anecdotal reports are closed-eye hallucinations (also known as closed-eye visualizations), and the ability to experience intense dreams while being high.

These reported closed-eye hallucinations resemble dream-like states where the users vividly visualize the thoughts that are going through their head, while they’re still awake.

The second effect is also undoubtedly fascinating, mostly because the majority of cannabis users don’t dream after using weed.

This happens because cannabis prolongs the deep-sleep phase of sleep, which reduces the time spent in the REM (rapid-eye-movement) phase, which is the stage where intense dreaming occurs.

It seems that the presence of melatonin changes something within the brain, which allows users to both experience and remember their dreams while under the influence of weed.

This effect could be considered useful, as it’s pretty frustrating to miss out on dreaming all the time, which affects heavy cannabis users the most.

Contrarily, the lack of dreaming can be extremely beneficial for other people, for instance PTSD patients, who suffer from recurring haunting nightmares.

Conclusion

Natural melatonin production is crucial, and much more important than using supplementation.

Ways to achieve this is to keep lighting low before you go to sleep (no phone/computer/TV), sleeping in pitch-black darkness, and making sure not to turn on the lights if you’re taking a trip to the bathroom in the middle of the night.

Morning or afternoon daylight/sunlight exposure are also beneficial for your body’s ability to produce melatonin in an adequate time-frame.

Besides regulating the circadian rhythm (sleep-wake cycle), melatonin is also a potent antioxidant and free-radical scavenger (3).

This implies that sufficient melatonin levels diminishes the risk of cancer (4), and de-accelerates the aging process (among numerous other benefits).

Lab-made synthetic melatonin supplements are usually made in pill form, and liquid sublingual products act the fastest, as they are absorbed directly into the bloodstream (unlike melatonin pills which have to pass through the digestive tract).

Melatonin supplements should not be used if you’re pregnant or you’re breastfeeding, if you suffer from an autoimmune disorder, depression or a seizure disorder.

People suffering from high-blood pressure and diabetes should check with their healthcare practitioner before using melatonin supplements.

These supplements can also potentially increase blood pressure levels and raise blood-sugar in patients taking certain hypertension drugs.

To conclude, if you’re determined to experiment with weed and melatonin make sure to start low and go slow, and avoid continuous use at all costs, because we just don’t know if this combination is damaging to one’s health in the long run.

Find out how weed influences melatonin production, and what to expect when combining cannabis and melatonin together.