In parasitic worm infection both the host and the worm produce cannabis-like molecules
Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a “wild” new discovery by an interdisciplinary research team at the University of California, Riverside.
The research, done on a mouse model, identifies cell signaling pathways associated with the endocannabinoid system that could be targeted to develop therapeutic treatments aimed at eliminating worm infection or improving infection outcomes.
Endocannabinoids are cannabis-like molecules made naturally by our own body to regulate several processes: immune, behavioral, and neuronal. As with cannabis, endocannabinoids can enhance feeding behavior and reduce pain and inflammation.
“Upon worm infection, the host’s intestines produce these cannabis-like molecules maybe as a safety net to dampen pain response,” said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences at the UCR School of Medicine and co-leader of the research project. “What we now have found is that the worms, too, are producing these natural cannabinoids throughout the infection process and especially when the worms penetrate the skin, further dampening the host’s pain response.”
Study results appear in the journal Infection and Immunity.
“Until now, no one had investigated endocannabinoids in worm infection,” said immunologist and senior author Meera G. Nair, an assistant professor of biomedical sciences in the UCR School of Medicine, who co-led the research project along with DiPatrizio. “We found that endocannabinoids are elevated following worm infection, and they contribute to optimal worm expulsion from the host’s body. This is a protective pathway that operates within infection that we were unaware of before. To increase its chances of survival, the worm may use this pathway so the host increases its feeding behavior — that is, eats more food — and it can also reduce tissue damage that inflammation and pain cause.”
The endocannabinoid system is present in all mammals, but recent studies suggest that it may be more primitive. Indeed, one study reported that black truffle mushrooms make anandamide, a type of endocannabinoid, possibly as a mechanism to attract truffle hogs that eat the truffles and disperse their spores. The worm C. elegans also has an endocannabinoid system that may operate to regulate its feeding.
“This system is known to dampen pain responses,” said DiPatrizio, a physiologist specializing in endocannabinoid research. “Upon worm infection, the host’s intestines produce these cannabis-like molecules maybe as a safety net to dampen pain response. What we now have found is that the worms, too, are producing these natural cannabinoids throughout the infection process and especially when the worms penetrate the skin, further dampening the host’s pain response. This is advantageous to the worm because if the host could detect these parasites, it would respond to kill them. It’s a pro-survival signaling pathway in the body that may have a therapeutic advantage in treating worm infection.”
Parasitologist Adler R. Dillman, a co-author on the paper, was surprised to find helminths naturally producing cannabis-like molecules in their own bodies.
“We were taken aback by this finding,” said Dillman, an assistant professor in the UCR Department of Nematology. “It may be important in other infections as well. Consider that the endocannabinoid pathway is present in almost all the worms we examined in this study. What it is telling us is that the pathway is evolutionarily conserved across a vast number of species. This clearly is an old and important system in the body that predates humans.”
Dillman’s lab found that N. brasiliensis, a gastrointestinal parasite of rats and a widely-studied helminth parasite, produces endocannabinoids, especially anandamide. A bioinformatic search of parasitic worm databases revealed this system is conserved within many parasitic nematodes, including the most prevalent helminths of man: roundworm and hookworm.
For Nair, this is the team’s “wildest discovery, its biggest finding.”
“It could impact behavior, pain, and host-helminth interactions,” she said. “Without the endocannabinoid system, infected hosts would have bigger worm burdens. In the lab, when we inhibited this pathway in mice, they were worse off — they ended up with more worms in their bodies.”
Nair, DiPatrizio, and Dillman recently received a two-year, $275,000 grant from the National Institutes of Health to further pursue the research and investigate how the endocannabinoid system affects immune response.
“Our current study focused on hookworms; we are ready now to investigate other helminths,” Nair said. “We will investigate whether the host and worm induce endocannabinoids so that the host may have less tissue inflammation and may have improved feeding behavior. Since the worms depletes the host of nutrients, it would make sense that they would trigger strategies to improve feeding.”
Nair, a hookworm expert, explained that hookworms bite the intestine and feed on blood, leading to micro-injuries and likely localized pain throughout the well-innervated intestine.
“Since endocannabinoids relieve pain and inflammation, local endocannabinoid production may be beneficial for the host, and perhaps the worm to still remain undetected by the host,” she said. “We plan to investigate this further.”
“The anti-inflammatory endocannabinoid system gives us insight into potential therapeutic targets for not only hookworm infection, but also celiac disease and inflammatory bowel disease,” said DiPatrizio, whose laboratory is also the only one at UCR authorized to study the impact of cannabis exposure, which hijacks the endocannabinoid system, on a host of pathologies and behavior, including gastrointestinal function.
Dillman stressed that until now no one knew worms were manipulating the endocannabinoid pathway.
“Our work has provoked more interesting research questions for us to pursue, and could lead to promising treatments,” he said. “We are at just the initial point of discovery.”
Nair, DiPatrizio, and Dillman were joined in the research by UCR’s Hashini M. Batugedara, Donovan Argueta, Jessica C. Jang, Dihong Lu, Jaspreet Kaur, and Shaokui Ge; and the University of Minnesota’s Marissa Macchietto.
The research was supported by grants from the National Institutes of Health. The UCR School of Medicine provided additional support.Like mammals, parasitic worms have an endocannabinoid system that may help the worm and the hosts it infects survive by reducing pain and inflammation in the host, according to a discovery by an interdisciplinary research team. The research, done on a mouse model, identifies cell signaling pathways associated with the endocannabinoid system that could be targeted to develop therapeutic treatments aimed at eliminating worm infection or improving infection outcomes.
Ted Emanuel Wellness /Solutions
Your health is your greatest asset!
Hemp seed Medicine: The Healing & Nutritive Qualities of Hemp seed (CBD’s)
Long before modern science discovered the beneficial biochemical actions of hempseed’s nutrient, the medicinal properties of hempseed were widely used in the herbal medicine of both the East and West. To avoid confusion, in this section I’ll cover the medicinal properties only of cannabis seeds, and not those of the THC-rich cannabis flowers and leaves.
The Greek physician Dioscorides (c.A.D. 40-90) recorded the use of hempseed for medicine as well as for food. In his work De Materia Medica, one of this millennium’s most authoritative herbal and pharmacological information resources, he extols Cannabis sativa for its medicinal benefits and recognizes hemp’s value for stout cordage. Dioscorides also had the honor of giving our favourite plant its botanical name.
In the early centuries A.D. in Europe it was common to use hempseed oil (juice) as an analgesic for earaches and for expelling insects from inside the ear. Galen (A.D. 129-c.199), a famed physician and philosopher, believed that gout is caused by overindulgence. He found hempseed useful in the treatment of this painful disease. Pliny the Elder (A.D. 23-79) prescribed infusion of hemp root to ease the inflamed joints of gout sufferers. Pliny was also the first known to prescribe hempseed as a laxative for farm animals.
Hempseed was also used quite extensively throughout Asia. Whether in the form of oil, decoction, powder, infusion, paste, or whole, it was a vital ingredient in many formulas.
The Chinese whose common name for hempseed is huo ma ren, Offer the most extensive medicinal information on it, most notably in Pen T’sao Kang Mu, China’s pharmacopoeia complied by Li Shih Chen. In addition to the wealth of information and prescriptions packed into this work’s large section on cannabis seed, there are numerous recipes, formulas, and preparation methods.
The Chinese attribute the following medicinal properties to cannabis seed: The seed’s energetics are sweet and neutral. Meridians and organs affected are the spleen, stomach, colon, and large intestine. Properties are demulcent (soothes, protects, and nurtures intestinal membranes), nutritive (nourishing to the body), laxative (loosens, relaxes, or stimulates evacuation of the bowels), diuretic (increases blood flow through the kidneys and thus augments urination), anthelmintic (destroys and dispels parasites such as worms), and mild yin tonic.
According to the following bits and pieces of modern and ancient prescriptions found in Chinese medicinal texts, cannabis seed:
- Is a chi (life force) tonic
- Can be used to hasten childbirth where the delivery is troubled with complications, or overdue
- Is indicated for postpartum recovery, for blood deficiency, and following febrile (fever) diseases
- Will alleviate retained placenta illness in mothers just beginning to suckle their infants
- Increases the flow of mother’s breast milk
- Is indicated in menstrual irregularities, constipation due to intestinal dryness, and wasting thirst
- Is commonly prescribed to treat constipation, particularly in the elderly
- Is indicated for dysentery
- Is used as a treatment for obstinate vomiting
- Is contraindicated for diarrhea
- Is used as an assisting herb in formulas to treat ulcers and sores
- Is helpful in reducing blood pressure
- Can break up long-standing problems with the blood flow
- Will restore the blood, the pulse, and the veins and arteries
- Improves the urinary tract and the passing of urine
- Has the capacity to cure zhong feng (neurologic impairment due to stroke) and the problems of excess sweating that this brings on
- Serve as a treatment for edema and its accommodation of diluted lymph
- Promotes healthy hair and skin
- Accelerates hair growth
Excerpt from ‘THE HEMP COOKBOOK” by Todd DalottoLong before modern science discovered the beneficial biochemical actions of hempseed’s nutrient, the medicinal properties of hempseed were widely used in the herbal medicine of both the East and West. To avoid confusion, in this section I’ll cover the medicinal properties only of cannabis seeds, and not those of the THC-rich cannabis flowers and leaves.… ]]>