CBD for Thyroid Disorders
In America, approximately 20 million people suffer from some kind of thyroid disorder, and close to 60 percent of the affected don’t know about their condition. According to the American Thyroid Association 1 women are a lot more likely to experience thyroid problems than men. Doctors usually prescribe traditional medicines to people with thyroid problems. However, the medicines may not always work. In fact, they could end up presenting quite a few side effects. People are, therefore, seeking refuge in alternative medicines. Many studies indicate CBD can be effective at treating an array of thyroid-related issues.
Found in the endocrine system, your thyroid gland is a vital organ. It’s a butterfly-shaped, small gland located below your voice box and in front of your neck. The gland produces and gives out two important hormones – T4 (tetraiodothyronine) and T3 (triiodothyronine) – that control your body’s metabolism and determine how your cells utilize energy. Also, the gland manages the pace of several processes, which include heart rate and body temperature. Generally, body metabolism management is critical for regulating weight, mood, and physical and mental energy levels.
Moreover, the thyroid gland converts the food you ingest into energy so that your body keeps functioning properly. Several thyroid problems are due to an atypical secretion of thyroid hormones. However, all kinds of thyroid disorder/disease have unique causes, risks, and diagnoses. It’s worth noting that many studies are pointing at how CBD could be potentially beneficial in treating thyroid diseases.
CBD and the Endocannabinoid System and Their Direct Impact on the Thyroid Hormone Release
The human body’s ECS (endocannabinoid system) exerts its strong influence in different ways. For instance, it regulates poise within various processes, such as thyroid function. According to an article published by National Institute of Health (NIH) 2 , scientists have discovered that the thyroid gland’s cells have cannabinoid receptors on them.
Multiple regulations and restrictions have made it quite difficult for researchers to learn more about cannabinoids and what role they play in the treatment of a thyroid disorder. Even though human-based research on the matter isn’t extensive yet, a study 3 was carried out on animals in 2002. It discovered that CB1 receptors control thyroid hormone release. Also, it was found cannabinoids administration had a say in thyroid hormonal activity. In 2015, another 2 was carried out by the NIH, which discovered cannabinoid receptors can theoretically be therapeutic targets for benign and malignant thyroid lesions.
Furthermore, a research study 4 carried out by the Journal of Endocrinology exhibited that endocannabinoid receptors are situated within the sections of the brain. The receptors transmit signals to the gland. This shows the likelihood of cannabinoids, such as CBD, influencing the thyroid gland’s performance and overall health.
Different thyroid disorders
A thyroid disorder is a condition that impacts the thyroid gland. Different kinds of thyroid disorders either affect the gland’s function or its structure. A disorder is usually linked to the glands either releasing excessive thyroid hormones (hyperthyroidism) or too little hormones (hypothyroidism). Other specific thyroid disorders are:
What is hyperthyroidism
Hyperthyroidism is a thyroid condition that indicates denotes an overactive thyroid gland. One out of every 100 women 5 could be suffering from this condition. It’s not common in men, however. Several conditions could cause hyperthyroidism, which includes excess iodine consumption, thyroid inflammation, tumors of the testes or ovaries, benign pituitary or thyroid gland tumors, and large quantities of tetraiodothyronine administered through medication or dietary supplements.
Grave’s disease is among the major causes of hyperthyroidism, found in approximately 70 percent of people with a hyperactive thyroid. It induces antibodies to push the thyroid into secreting too much hormone. Thyroid nodules could also cause the thyroid gland to produce its hormones in excess. This condition is called multinodular goiter or toxic nodular goiter. Increased thyroid hormone production could present the following symptoms:
- racing heart
- increased sweating
- trouble sleeping
- brittle nails and hair
- thin skin
- weight loss
- muscle weakness
- bulging eyes
How CBD can help treat hyperthyroidism
Patients with hyperthyroidism usually report major or minor relief from negative symptoms of their disease. Regularly using CBD oil for thyroid helps individuals normalize their body weight, by putting an end to diarrhea issues and reestablishing their appetite. CBD for thyroid disorder gets rid of irritability and anxiety-related sleep disorders. Moreover, CBD for thyroid disorder helps with heart function regulation, the trembling of fingers and hands, and muscular aches, if any.
Does CBD affect thyroid medication?
There has been no clinical evidence showing interactions between CBD and thyroid medication such as Levothyroxine. A good way to get an idea if CBD will interact with your thyroid medication is to look for the “grapefruit warning” on the label.
More than 85 drugs 6 interact with grapefruit, however no thyroid medications are present on that list.
Nonetheless, we always recommend you read the label of your medication carefully and always consult with a doctor before taking CBD in combination with any medication.
What is hypothyroidism
Hypothyroidism is the reverse of hyperthyroidism. In this case, the thyroid gland is unable to produce enough hormones or is underactive. This disorder usually follows Hashimoto’s disease, the damage inflicted by radiation treatment, or thyroid gland removal surgery. While not all individuals with Hashimoto’s exhibit hypothyroid signs, thyroid antibodies could be the marker for thyroid diseases in the future. Most hypothyroidism cases are mild, with the symptoms being:
- memory problems
- dry skin
- heightened sensitivity to cold
- weight gain
- decreased sweating
- loss of libido
- slow heart rate
How CBD oil can help treat hypothyroidism
People with hypothyroidism issues would notice alleviation or total elimination of distressing headaches, and pain in the joints and muscles when using CBD oil. CBD lets restore the restful sleeping tendencies of the patient. Moreover, it helps increase concentration levels and eliminates depression and arduous tension.
What is Hashimoto’s disease
Also called chronic lymphocytic thyroiditis, Hashimoto’s disease is one of the most common hypothyroidism causes. It could affect a person at any age, but middle-aged women are most likely to be affected. The disorder manifests when your immune system erroneously attacks and slowly annihilates the thyroid gland, along with its ability to make hormones. Some individuals with minor instances of this disease may not show obvious signs. In fact, the disease could stay stable for several years, with the symptoms often being subtle. Also, the symptoms aren’t specific. In other words, they share symptoms of several other conditions, which include:
- mild weight gain
- dry, thinning hair
- dry skin
- irregular and heavy menstruation
- puffy, pale face
- intolerance to cold
- goiter or enlarged thyroid
How to use CBD oil for Hashimoto’s
Hashimoto’s disease is literally a condition affecting the body, mind, and spirit. CBD oil for Hashimoto’s responds well to the innate cannabinoid substances of your body. CBD oil and Hashimoto’s are usually talked about in the same sentence because CBD sustains and balances the homeostasis of your body, and Hashimoto’s disease like other thyroid diseases is due to an imbalance in your body’s normal functioning. Anecdotal reports about efficient and successful treatment with CBD oil and Hashimoto’s involved corroborate these claims.
What is Thyroiditis
Thyroiditis is composed of multiple disorders that lead to thyroidal inflammation, which could either cause abnormally low or high thyroid hormone levels in the blood. Thyroiditis is usually caused when the thyroid is attacked, leading to thyroid cell damage and inflammation. The disease is typically considered as an immune system malfunction. The cause could be bacteria- or virus-induced infection. Moreover, some drugs could trigger thyroiditis due to their tendency to damage thyroid glands.
The different kinds of thyroiditis are Hashimoto’s thyroiditis (a very common hypothyroidism cause), postpartum thyroiditis (typically triggered after delivering a child), silent thyroiditis, subacute thyroiditis, radiation-induced thyroiditis, drug-induced thyroiditis, Riedel’s thyroiditis, and acute thyroiditis. Each of these thyroiditis types has its unique causes, risks, and diagnoses.
There are multiple symptoms and signs of thyroiditis, due to the various types. These could comprise:
- weight gain
- cold intolerance
- muscle cramps
- dry hair and skin
- decreased concentration
- leg swelling
- puffy eyes
When the condition becomes severe, the symptoms include low body temperature, slow heart rate, coma, and heart failure.
How CBD can help treat thyroiditis
Due to thyroiditis’ immunomodulatory traits, CBD ushers in positivity by not just alleviating thyroiditis symptoms, but also by coming down hard on the hampering inflammatory process. Though these assumptions haven’t been confirmed scientifically, they certainly help us view the conceivable inhibition of thyroid cells’ destruction courtesy cannabidiol’s positive attributes and action.
CBD oil Dosage for Thyroid Disorders
While there are more than a handful of ways to use CBD for treating thyroid disorders, high-quality CBD oil is the most effective and potent method. Oils, by nature, are molecular carriers, which means they can carry a lot more cannabinoid molecules than any other type of CBD product. Moreover, CBD oil can be ingested easily and absorbed quite efficiently when the drops are directed below the tongue and kept there for some 30 to 90 seconds prior to swallowing.
If you are just getting started, it’s recommended you administer the drops no more than three times a day.
Determining the correct CBD dose for a thyroid disorder will depend on the severity of your symptoms. Since everyone’s reaction to CBD is different, it is important to listen to your body and regulate the dose while looking for signs of improvement.
We recommend following the step up approach established by Leonard Leinow and Juliana Birnbaum in their book “CBD: A Patient’s Guide to Medicinal Cannabis” 7
You can read about the step-up approach and calculate what CBD dose is right for you in our post on CBD dosage.
The most impressive thing about CBD oil treatment for thyroid disease is the single medication approach. It can be used for treating virtually every and any kind of thyroid malfunction – be it hyperthyroidism, hypothyroidism, thyroiditis, or goiter. Several anecdotal pieces of evidence pertaining to CBD’s efficiency and efficacy in treating thyroid disorders have been documented. Moreover, multiple scientific studies have showcased the therapeutic regulatory effects of cannabinoid on the thyroid gland. Though not a lot of specific clinical trials have been carried out on CBD oil for thyroid diseases, the growing understanding of how CBD works with the internal endocannabinoid system is enough material to give life to the notion that CB receptors could play a major part in homeostatic thyroid regulation, along with correct cell-to-cell interaction between the brain, thyroid, and the body’s system of organ structures.
If you wonder why there is the mention of only CBD and not its family members, marijuana or THC, for treating thyroid disorders, it is because CBD constitutes the plant’s non-psychotropic cannabinoid. In other words, it won’t give you the feeling of “high” by itself. Not to mention, most people wanting to use cannabis for its medical traits are usually least interested in the drug’s mind-altering effects.There are several different Thyroid Disorders which could all benefit from the healing properties of CBD Oil. Read more about the effects of CBD on Thyroids
What drugs should not be taken with CBD?
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- CBD interaction with drugs & medication
- Drugs that should not be taken with CBD
- Does CBD oil affect blood pressure?
- Does CBD oil thin the blood?
- Does caffeine counteract CBD?
Cannabis is a complex plant, with hundreds of chemicals and over 100 distinct cannabinoids. The little research that examines cannabidiol or CBD, the second most common cannabinoid found in cannabis, shows evidence of potential health benefits for a wide range of conditions. As CBD becomes more mainstream, however, a key question comes to mind, “How will CBD interact with my current medication?”
Currently, sparse research suggests that CBD can illicit problematic interactions with certain other prescription drugs. The findings are far from conclusive — further research is still needed on CBD’s interaction with different medications. Many doctors and researchers urge individuals using CBD medically or recreationally to be cautious about mixing it with other prescriptions and to consult healthcare providers about possible interactions.
Many doctors urge individuals using CBD to be cautious about mixing it with other prescriptions and to consult healthcare providers about possible interactions.
CBD interaction with drugs & medication
Have you heard of the grapefruit test? Many prescription drugs will include grapefruit warnings on the label, advising against consuming the citrus fruit while taking medication. Many medications are broken down in the liver and small intestine by a group of proteins called cytochrome P450 enzymes (CYPs). This process is what delivers a medication’s benefits to the intended target.
Grapefruit disrupts the activity of CYPs and slows the way these proteins usually break down medication. The fruit also increases the side effects and duration the drug stays in the system. One 2013 study titled “Grapefruit Medication Interactions: Forbidden Fruit or Avoidable Consequences?” published in the Canadian Medical Association Journal showed that grapefruit can increase blood content levels when interacting with at least 85 different drugs. The reported consequences were severe, including irregular heartbeat, organ failure, internal bleeding, and death.
Further, a 1993 study conducted by pharmacology researchers at the University of California, San Francisco, and published in the journal Biochemical Pharmacology, discovered that CBD, much like grapefruit, disrupts the normal function of cytochrome P450 enzymes in mice. The study postulated that while the blockage could allow patients to take lower doses of their prescriptions, it could also cause a toxic buildup of chemicals in the body. Since this study’s publication, several scientific and medical journals have published evidence of the grapefruit-like effects of CBD in humans.
The type, quality, and purity of CBD administered all affect how it interacts with your body and medication. The timing of when you take CBD and any other prescription drug also factors into how the two may interact in your body. And of course, every individual responds to medications differently, depending on genetics, age, weight, and other factors.
The type, quality, and purity of CBD administered all affect how it interacts with your body and medication. Photo by: Gina Coleman/Weedmaps
Let’s examine the current research on CBD’s interaction with several common prescription and over-the-counter medications.
Should I take CBD with ibuprofen?
Ibuprofen is a nonsteroidal anti-inflammatory (NSAID) medicine that reduces pain and inflammation in the body. Ibuprofen has a risk of blood-thinning and can cause dizziness, shortness of breath, and nausea.
Potentially, CBD can increase the duration and strength of ibuprofen, thereby increasing the risk of adverse side effects. No human studies to date examine CBD’s interaction with NSAIDs specifically. Still, two studies conducted on animal models in 2006 and 2008 and published respectively in the journals, Pain and Pharmacology, suggest that other cannabinoids may work synergistically with NSAIDs like ibuprofen to reduce pain.
Patients should consult with their healthcare provider before taking ibuprofen with CBD.
Should I take CBD with warfarin?
Warfarin, also known under the brand name Coumadin, is an anticoagulant (blood thinner) medication used to prevent the formation of harmful blood clots that could potentially cause heart attacks or strokes. Warfarin’s risks include severe bleeding, headaches, swelling, or sudden pain in extremities.
In 2017, researchers at the University of Alabama, Birmingham, conducted a study published in Epilepsy & Behavior Case Reports which showed that CBD increases the effects of drugs used for blood-thinning by slowing down how the body metabolizes warfarin and prolonging its presence in the system. By increasing the duration of warfarin’s presence in the body, CBD could potentially exacerbate some of the associated risks.
Patients taking generic warfarin or Coumadin should consult their healthcare provider for individualized information and get blood tests before beginning a CBD regimen.
Should I take CBD with thyroid medication?
Thyroid medication is used to treat thyroid disorders, most commonly hypothyroidism (an underactive thyroid) via thyroid hormone replacement, and hyperthyroidism (an overactive thyroid) via anti-thyroid medication. Different medications achieve these objectives through different pathways in the body. Side effects of thyroid hormone replacement therapies include chest pain, anxiety, headaches, and vomiting. While rare, anti-thyroid medication side effects can include rash, itching, fever, aches, and headaches.
Little research studying interactions between CBD and common thyroid hormone replacement and anti-thyroid medications currently exists. Patients taking thyroid medication who want to try CBD should consult with their physician.
Should I take CBD with Eliquis?
Eliquis (generically called apixaban) is a blood thinner used to lower the risk of stroke or a blood clot in veins, the heart, the lungs, and the legs following knee or hip replacement surgery. Eliquis increases the risk of severe bleeding, and patients taking Eliquis are typically prescribed precise dosages by their doctor.
CYP proteins process Eliquis in the liver, the same proteins on which CBD acts to delay metabolization. This process could cause an overdose of Eliquis’ chemicals in the body and a high risk of severe bleeding.
Patients taking Eliquis should speak to their doctor before using CBD products.
Should I take CBD with Plavix?
Plavix is the brand name of the drug clopidogrel, frequently prescribed for patients who have had or are likely to have a heart attack. The drug works by blocking blood platelets from forming clots in arteries near the heart.
According to a 2011 study published in the journal Life Sciences, it is possible that CBD has an inhibitory effect on CYP2C19, the enzyme that metabolizes Plavix. This could cause Plavix to remain longer in the body and weaken its overall effects. Further research is required to determine whether this could lower Plavix’s effectiveness in preventing heart attacks.
Patients using Plavix or clopidogrel should consult their physicians as to whether they should use CBD.
Should I take CBD with Tylenol?
Acetaminophen, the generic name for Tylenol, is a common drug used for pain and fever relief. Acetaminophen carries a risk of liver damage and disease, with side effects including nausea, headaches, and insomnia.
Acetaminophen and CBD both are metabolized by CYP450, which lowers the effectiveness of both chemicals as they’re processed in the body. One controversial 2019 study, conducted by the University of Arkansas on mice and published in the journal Molecules, claimed that high doses of CBD contributed to liver toxicity, which could compound acetaminophen’s liver damage potential. However, the study’s authors have been accused of cherry-picking research and designing experiments to showcase potential CBD toxicity. The one study they cited with human test subjects did not show liver toxicity from CBD.
More research is required to confirm potential interactions between CBD and acetaminophen. Patients looking to take both simultaneously should consult their physician.
Should I take CBD with metoprolol?
Metoprolol is a beta-blocker designed to treat high blood pressure by reducing the heart rate and changing the release of epinephrine, a hormone involved in stress and other processes. Beta-blockers lower blood pressure and sometimes produce side effects such as dizziness, nausea, stomach pain, heartburn, and cold hands and feet.
No studies have examined potential interactions between CBD and metoprolol. However, some placebo-controlled research conducted on healthy people at the University of Nottingham in England and published in 2017 in the journal JCI Insight has linked CBD with decreased blood pressure when taken on its own. For patients taking metoprolol, however, the combination with CBD could potentially have negative impacts on blood pressure.
A 2011 study performed on mice and published in the British Journal of Pharmacology also shows that CBD has potential nausea-reducing properties, which may help soothe side effects associated with metoprolol.
Patients taking metoprolol or other beta-blockers should consult their doctor as to whether to consume CBD.
Should I take CBD with metformin?
Metformin is a medication prescribed to adults with type 2 diabetes to help control blood sugar levels. Side effects of metformin include low blood sugar, nausea, diarrhea, vomiting, and muscle pain.
One 2006 study published in the journal Autoimmunity showed that CBD reduced the incidence of diabetes in animal models. To date, however, very little research has specifically covered CBD’s potential in human diabetes treatment or interactions with metformin. Only one study, conducted by the American Diabetes Association and published in 2016 in the journal Diabetes Care, has examined the efficacy of CBD in patients with type 2 diabetes and found it had no significant impact on glucose levels.
More research is needed on CBD’s interaction with diabetes. Patients taking metformin should talk to their doctor about whether CBD is right for them.
Should I take CBD with Xanax?
Xanax (generic name alprazolam) is a benzodiazepine medication used to treat panic disorders, anxiety, and depression. Common side effects of Xanax include drowsiness, lack of coordination, memory loss, and early-morning anxiety.
Xanax breaks down in the liver via an enzyme called CYP3A4, which is inhibited by CBD. Taking CBD could potentially increase the amount of time Xanax is in the system and prolong or increase the likelihood of unwanted side effects. CBD may one day be considered an alternative to Xanax as various research, including a 2011 study published in the journal Neuropsychopharmacology, has documented the cannabinoid’s potential anti-anxiety properties.
No research has explicitly documented interactions between Xanax and CBD. Patients taking Xanax who are interested in CBD should speak to their healthcare providers for more information.
Should I take CBD with statins?
Statins are a classification of drugs designed to lower cholesterol and protect against heart attack and stroke. Common side effects of statins are muscle soreness, blood sugar increase, headaches, and nausea.
Statins are processed by CYP function in the liver, which CBD inhibits. While no research has specifically studied interactions between statins and CBD, the cannabinoid could potentially increase the strength and duration of statins in the system and the risk of unwanted side effects.
Patients taking statins should speak to their healthcare provider before using CBD.
Drugs that should not be taken with CBD
CBD’s documented effects on liver function and enzymes that metabolize several medications are relevant when considering whether or not to consume CBD with certain drugs. CBD acts on the same metabolites as grapefruit — therefore, many of the prescription drugs that carry grapefruit warning labels may have similar risks when taken with CBD.
CBD acts on the same metabolites as grapefruit — therefore, many of the prescription drugs that carry grapefruit warning labels may have similar risks when taken with CBD. Photo by: Gina Coleman/Weedmaps
These drug classifications include a large percentage of existing prescriptions, such as benzodiazepines, antihistamines, haloperidol, antiretrovirals, statins, cyclosporine, sildenafil, warfarin, and other drugs metabolized by CYP3A4 and CYP2D6.
Clobazam, used to treat epileptic seizures, is another type of drug that may not be advisable to take in conjunction with CBD. However, Epidiolex is an FDA-approved, CBD-based drug that physicians may prescribe to treat epilepsy. A significant amount of data, derived from clinical trials, exists on Epidiolex, although the drug can also cause adverse effects, according to a 2019 study conducted by researchers at Columbia University and published in the journal F1000Research.
No research conclusively warns patients against taking these drugs with CBD, though the previously cited 2013 study published in the Canadian Medical Association Journal has shown that grapefruit and drug interactions can lead to severe effects, including irregular heartbeat and sudden death, kidney failure, and muscle damage. Every patient’s case is unique, and individuals should speak to their healthcare providers if they are considering taking CBD in combination with particular prescription medications.
Does CBD oil affect blood pressure?
A previously cited 2017 study titled, “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study” published in the journal JCI Insight, supports CBD’s ability to lower blood pressure. Researchers also suggest that the anxiety- and stress-reducing properties of CBD may contribute to the overall ability to lower blood pressure. However, CBD taken with blood pressure medication or beta-blockers could potentially cause both drugs to double up on each other and lower blood pressure to unhealthy levels.
Does CBD oil thin the blood?
No research shows that CBD oil taken on its own can thin the blood. CBD oil does increase the effects of blood-thinning medications, such as warfarin, and could potentially push the presence of warfarin beyond therapeutic levels, as the previously cited 2017 study published in Epilepsy & Behavior Case Reports showed.
Does caffeine counteract CBD?
Caffeine and CBD are two substances gaining in popularity, particularly when they’re mixed. Caffeine can keep sleep-deprived individuals alert and clear-headed. Further, a 2007 study on rats published in the journal Pharmacology Reports showed that caffeine is metabolized by CYP enzymes, which CBD inhibits. This could extend the time caffeine stays in the body and has the potential to extend the stimulating effects of caffeine.
The information in this article is based on current research and should not be construed as medical advice. Please speak to your doctor or healthcare provider if you have questions regarding your medication and CBD use.What drugs should not be taken with CBD? Copy article link to clipboard. Link copied to clipboard. Contents CBD interaction with drugs & medication Drugs that should not be ]]>