CBD Oil for Osteoporosis
According to the International Osteoporosis Foundation 1 , this condition affects an estimated 75 million people in Europe, the United States, and Japan. It is estimated to affect 200 million women worldwide – approximately one-tenth of women aged 60.
What is Osteoporosis?
Known also as “porous bones”, this medical condition causes bone loss. It’s the loss of tissues, thus resulting in fragile and brittle bones. This means that patients with Osteoporosis have poor bone health as these parts have a lowered density. This makes them especially prone to fractures or other injuries. In worse cases, this disease might deform the normal physical structures. Osteoporosis can trigger issues such as spine deformities.
Symptoms & Causes for Osteoporosis
There are typically not many symptoms in the early stages of Osteoporosis. Once your bones have been weakened by the bone loss, you may have signs and symptoms that include:
- Back pain, caused by a fractured or collapsed vertebra
- Loss of height over time
- A stooped posture
- Bone fracture that occurs much more easily than expected
Women are more likely to develop Osteoporosis. This is because they can quickly lose bone mass in the first couple of years after menopause.
Other risk factors could include:
- Overactive adrenal glands
- Overactive thyroid
- Low level of sex hormones
- Using corticosteroids for a long time
- Medical issues like inflammatory or hormone-related conditions
- A lower BMI than average
- Heavy drinking and smoking
- Frequent use of medications which affect bone strength, bone density or hormone levels negatively
Why can CBD oil work for Treating Osteoporosis?
Over the past few decades, researchers have found out the presence of some cannabinoid receptors such as CB1 and CB2 in bone tissues. Indeed, these elements play an essential role in bone health.
CB2 is expressed predominantly in osteoclasts (bone-resorbing cells) and osteoblasts (bone-forming cells). This kind of cannabinoid receptor is necessary for the regulation of your bone metabolism. Physiologically, it is important to keep a balance between osteoclasts and osteoblasts as it would maintain optimum bone health. As people age, this balance would be impaired, and result in bone fractures or loss of bone density.
CB2 agonists like cannabidiol (CBD) could be used to modulate the functions of these receptors 2 . They can improve the activity and count of osteoblasts while inhibiting the expression of osteoblasts and the proliferation of osteoclasts. These elements can also stimulate the formation of Endocortical bones, suppress bone losses and maintain a normal mass of bone. CB1 receptors, on the other hand, can be activated to inhibit a chemical known as norepinephrine 3 .
This element might delay the formation of your bones and the bone density, adjust the rate of reabsorption and lead to some bone issues.
Recent studies have proven that the use of Cannabidiol (CBD) oil can have positive effects on these receptors, thus alleviating symptoms as well as slowing the progression of osteoporosis.
CBD oil is available in various forms and concentrations, including liquid or thick paste, oil, capsules, gum or candy, salves, sprays or drops, and vapor.
What are the Benefits of Using CBD oil for Osteoporosis?
Over the years, studies have shown that CBD oil and other CBD products have 2 distinct benefits in osteoporosis treatments. Firstly, it would negatively modulate CB2 and CB1 receptors, thus reducing their capability of binding to agonists, a compound which activates them 4 . This is often called the entourage effect, meaning that using CBD oil can help reduce the effects of other compounds that serve as the same cannabinoid receptors.
What’s more, CBD can inhibit several enzymes such as FAAH and increase the effects that they would exert on these cannabinoid receptors. As a result of these effects, researchers have suggested that CBD is effective and helpful in lowering the risks of bone problems and enhancing health.
The Endocannabinoid System & Bones
The Endocannabinoid System (ES) plays an essential role in the regulation of osteoclast and osteoblast activities 5 . This means if any problem happens in this area, it might lead to a number of conditions, including osteoporosis. There is also evidence to show your ES might determine the development of a low bone mass 6 . Indeed, a lack of the endocannabinoid receptors in your brain has been linked to a higher turnover of bone.
Essentially, your body might keep “retiring” old bone cells without producing enough new ones for replacement. However, if these receptors could be stimulated with the help of cannabidiol (CBD), the bones are more likely to maintain its function even after many years.
In general, the ES consists of cannabinoid receptors that are activated by several elements like CBD. The endocannabinoids are basically generated and degraded by a few types of enzymes, this giving this system a role in controlling some essential activities. Consequently, reduced numbers of endocannabinoid receptors are linked to the development of osteoporosis.
CBD oil dosage for Osteoporosis
As a rule of thumb, the dosage of CBD oil or for osteoporosis treatments can vary a lot depending on the level of intensity. It is advisable to start small and increase the CBD dosage gradually until you get the desired results. A standard dose of between 10mg and 100mg of CBD/dose/day is recommended by the CBD experts Leinow and Birnbaum in thier book CBD: A Patient’s Guide to Medicinal Cannabis.
The Step-up Method
An in-depth guide of how to dose your CBD has been given in the book CBD: A Patient’s Guide to Medicinal Cannabis by Leinow and Birnbaum 7 . The authors have introduced their Step-Up Method, where they recommend different types of dosage according to weight and condition. To find out how to follow Leinow and Birnbaum’s guide, read our post on CBD dosage.
Is CBD good for Osteoporosis?
A study by French scientists has suggested that human bones come with a higher level of endocannabinoids and ligands than brain cells 8 . Also, a naturally generated cannabinoid in our body named Anandamide could have an effect on the bone tissues. Anandamide helps to bind to those CB2 receptors. They also pointed out that CBD can imitate Anandamide, thus positively affecting bone health in those people who suffer from osteoporosis.
Another study by Idris Al focused on the important part of cannabinoid receptors in treating osteoporosis 9 . The results suggested that CBD is likely to affect bone metabolism and ligands. Therefore, these products can be used for bone fractures and other issues as they may be applied to exploit the cannabinoid receptors for targeting anabolic therapy and anti-resorptive.
A published study in 2015 by researcher Kogan Niemand 10 has found that when mice were treated with CBD oil, the maximal loads on their bones significantly increased. Also, he discovered that using CBD could speed up the process of healing fractures or broken bones, as well as slow down the loss of bone density.
As reported by the World Health Organisation (WHO), cannabidiol is considered safe and has few side effects.
Recent studies have shown that the use of CBD oils can have positive effects on alleviating symptoms as well as slowing the progression of Osteoporosis.
CBD and Osteoporosis – New Insights
Osteoporosis and low bone mass (osteopenia) represent a major public health threat here in the United States, affecting over 53 million American women and men aged 50 and older. To be clear, this represents more than half of the people in this age group.
Certainly, the main issue that people become concerned with when discussing osteoporosis is the dramatically increased risk of associated bone fracture, of which fractures of the vertebrae are the most common. Of course, associated hip fractures remain extremely important as well. In fact, as published in the Journal of the American Medical Association, nearly 65,000 women die from complications of hip fracture each year, and the risk of death within the first 6 to 12 months after hip fracture is an astounding 25%.
There are certainly many factors that contribute to abnormal thinning of the bone, like inadequate vitamin D, vitamin K, calcium, magnesium, and weight-bearing exercise. New research is honing in on the actual mechanisms that degrade bone. The density of bone, to a significant degree, represents the balance between the activity of two types of cells. Osteoblasts, which are involved in producing bone, and osteoclasts, which are the cells that degrade bone.
New research has identified a cell receptor on osteoclasts that, when activated, increases their activity and speeds bone degeneration. This receptor is known as the GPR55 receptor. In laboratory animals, administration of chemicals that stimulate this receptor turn on the action of osteoclasts, and subsequent loss of bone density.
One might assume that using an antagonist, or a chemical that blocks the GRP55 receptor, would reduce the activity of osteoclasts and help preserve bone density. In fact, that is specifically what was demonstrated in a study appearing in Proceedings of the National Academy of Sciences. In this study, the researchers demonstrated that cannabidiol (CBD) specifically blocked the activation of this receptor, and this effectively, and quite dramatically, reduced the activity of the osteoclasts, the cells that degrade bone.
Keep in mind that bone density represents the balance between making bone and degrading bone. When the cells that degrade bone, the osteoclasts, are inhibited, it allows the osteoblasts to work more effectively, tipping the balance in favor of increased bone density. This has been clearly demonstrated, at least in laboratory animals.
Further, other researchers have shown that bone healing after fracture takes place much more quickly, again in laboratory animals, when exposed to CBD.
As it relates to humans, there certainly isn’t much clinical research that yet verifies the utility of CBD in terms of reducing bone thinning or healing a bone fracture. Nonetheless, the idea of extrapolating from animal data is certainly nothing new in medical research. My purpose in presenting this information is simply to raise awareness as to where we are, currently, in this science. It is vey exciting, especially as we look towards the future in terms of what CBD, a naturally occurring chemical, could bring to the table for providing us with tools to treat many of the most severe maladies of our times.
Researchers have found that cannabidiol (CBD) may inhibit the work of cell receptors that are associated with degrading bone health.