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What Drugs Should Not Be Taken with CBD?

As you will see, many of these are cytochrome P450 enzymes, or CYP450s for short. Therefore, if you’re taking any prescription drug falling into the CYP450 enzymes category, it’s best to consult with a medical professional before starting a CBD regimen.

These drugs include:

  • CYP1A1 substrates (muscle relaxers and bronchodilators)
    • examples include: Lorzone and Theo-Dur
  • CYP1A2 substrates (antidepressants, antipsychotics, chemotherapy nausea drugs, beta-blockers, and calcium channel blockers)
    • examples include: Elavil, Haldol, Zofran, Inderal, Calan, and Isoptin
  • CYP1B1 substrates (proton pump inhibitors, antipsychotics, digestive system treatment drugs, and cancer medicines)
    • examples include: Prilosec, Clozaril, Prevacid, Eloxatin, and Tarceva
  • CYP2A6 substrates (sedatives, pain relievers, general anesthetics, antiepileptics, and medicines that block the body’s ability to metabolize alcohol)
    • examples include: Heminevrin, Penthrox, Fluothane, Depacon, and Antabuse
  • CYP2B6 substrates (anesthesia, epilepsy drugs, muscle relaxers, barbiturates, and corticosteroids)
    • examples include: Ketalar, Phenobarbital, Norflex, Seconal, and Decadron
  • CYP2C19 substrates (stomach acid drugs, proton pump inhibitors, benzodiazepines, pain relievers, and antivirals)
    • examples include: Prilosec, Prevacid, Protonix, Valium, Soma, and Viracept
  • CYP2C8 substrates (antiarrhythmics, anticonvulsants, antimalarial, nonsteroidal anti-inflammatories, anti-cancer drugs, and diabetes drugs)
    • examples include: Cordarone, Tegretol, Aralen, Voltaren, Taxol, and Prandin
  • CYP2C9 substrates (anti-inflammatories, ibuprofen, antidepressants, blood thinners, diabetes drugs, and hypertension meds)
    • examples include: Cataflam, Voltaren, Motrin, Mobic, Feldene, Celebrex, Elavil, Coumadin, Glucotrol, and Cozaar
  • CYP2D6 substrates (antidepressants, antiarrhythmics, antipsychotics, chemotherapy nausea drugs, selective serotonin reuptake inhibitors, and pain relievers)
    • examples include: Elavil, Norpramin, Tambocor, Haldol, Zofran, Paxil, Risperdal, Ultram, and Effexor
  • CYP3A4 substrates (benzodiazepines, calcium channel blocker, antibiotics, cholesterol meds, antihistamines, triazolobenzodiazepines, and antifungals)
    • examples include: Xanax, Norvasc, Biaxin, Mevacor, Allegra, Halcion, and Nizoral
  • CYP3A5 substrates (testosterone, progesterone, calcium channel blockers, and organ rejection meds)
    • examples include: Endometrin, Prometrium, Adalat CC, and Sandimmune)
  • CYP2C19 inhibitors (histamine receptor antagonists, selective serotonin reuptake inhibitors, stomach acid reducers, platelet blocking drugs, and seizure medications)
    • examples include: Tagamet, Luvox, Prilosec, Ticlid, and Topamax)
  • CYP3A4 inhibitors (antiarrhythmics, calcium channel blockers, antibiotics, and protease inhibitors)
    • examples include: Cordarone, Cardizem, Erythrocin, Crixivan, Fortovase, and Norvir)
  • CYP3A4 inducers (anticonvulsants, antiepileptic drugs, and antibiotics)
    • examples include: Tegretol, Dilantin, Mocobutin, and Rifampin
  • CYP2C19 inducers (anticonvulsants, corticosteroids, and antibiotics)
    • examples include: Tegretol, Deltasone, and Rimactane
  • Glucuronidated drugs (acetaminophen, benzodiazepines, analgesics, and antiretrovirals)
    • examples include: Tylenol, Serax, Haldol, Lamictal, Roxanol, and Retrovir)
  • Central nervous system depressants (benzodiazepines, pentobarbital, phenobarbital, fentanyl, morphine, and propofol)
    • examples include: Nembutal, Luminal, Seconal, Duragesic, and Diprivan
  • Anticonvulsants and anti-seizure meds
    • examples include: Eslicarbezepine, Rufinamide, Topiramate, and Zonisamide

Looking at this list can be more than a little overwhelming. However, there is a simpler way to help identify whether CBD could potentially interact with your prescription medication. It involves asking whether or not it is safe to drink grapefruit juice.

By default then, if you are unable to drink grapefruit juice while taking your prescription medication, it may be unsafe to take CBD as well.

In the end, if you currently take any prescription medications, it’s best to consult with your healthcare provider before taking CBD oil.

In some cases, this may involve starting with a low dose of CBD and only moving to high doses once you know it is safe to do so.

What Drugs Should Not Be Taken with CBD? As you will see, many of these are cytochrome P450 enzymes, or CYP450s for short. Therefore, if you’re taking any prescription drug falling into the ]]>