CBD for Seizures: Is it Safe and Effective?
Every day, we experience emotions, thoughts, and stimuli from our external environment. The way we experience these thoughts and sensations is through our central nervous system. Our central nervous system communicates through electrical signals between neurons, which are the cells that make up the brain.
Most of the time, this system functions normally. However, these electrical signals can become abnormal, and the brain can become over-excited. When this happens, it results in a seizure.
Exploring Using CBD for Seizures
Currently, the conventional treatments available for seizures do not control seizures in 30-40% of patients. In addition, many people report experiencing serious side effects with anti-seizure medications. There is a growing body of evidence to support using CBD for seizures. Both research and anecdotal evidence suggest that CBD products are an effective adjunct therapy in seizures and treatment of epilepsy.
CBD for Seizures: Just the Facts
Seizures result from the over-excitement of electrical signals in the brain. When a person experiences more than two seizures, they are typically diagnosed with epilepsy. Current antiepileptic drugs do not control seizures in a large portion of patients, and people are looking to alternative therapies such as CBD. Currently, the FDA has approved a prescription CBD product for the treatment of some types of seizures, and there is a growing body of evidence to support the treatment of seizures with CBD oil.
Seizures occur when there is a surge of electrical activity in the brain. The symptoms of a seizure depend on which areas of the brain are affected. For instance, some people begin to convulse violently, while other people stare blankly for a period of time. Epilepsy is diagnosed when a person has experienced at least two unprovoked seizures.
Type of Seizures
There are several types of seizures, which fall into two categories. The first type is focal seizures, and the second type is generalized seizures.
Focal seizures affect one part of the brain. There are two types of focal seizures:
- Complex focal seizures can cause a change in or loss of consciousness, as well as cause repetitive movements, including chewing, swallowing, or hand rubbing.
- Partial focal seizures do not cause a change in consciousness. They typically cause a change in emotions or the perception of how things look, smell, feel, taste, or sound. These kinds of seizures may also cause muscle twitches, numbness, or tingling.
Generalized seizures affect all parts of the brain. There are six categories of generalized seizures:
- Absence seizures are most common in children. They typically cause a person to stare into space and cause rapid blinking or lip smacking.
- Tonic-clonic seizures, also known as grand mal seizures, cause a person to fall to the ground and convulse. In these types of seizures, a person loses consciousness.
- Tonic seizures cause a person’s muscle to stiffen.
- Atonic seizures cause a person to lose their muscle control and collapse.
- Clonic seizures cause repetitive muscle jerking of the neck, face, and arms.
- Myoclonic seizures cause muscle jerks of the arms and legs.
Causes of Epilepsy
In the majority of cases, the cause of epilepsy is unknown. However, there are some risk factors for epilepsy, which include:
- Head trauma
- Brain infections
- Family history
Complications of Seizures
Complications of seizures depend on the type and severity of seizures. In convulsive seizures, there is a risk of falling or getting hurt. Additionally, there is a risk of status epilepticus—which are prolonged seizures—which can cause brain damage.
Dravet syndrome and Lennox-Gastaut syndrome, which are severe types of epilepsy that typically present in infancy or childhood, have a high risk of mortality. Currently, there is no antiepileptic medication that effectively treats Dravet syndrome or Lennox-Gastaut syndrome in the United States.
The current treatments available for epilepsy are antiepileptic drugs and other anti-seizure medications. In some cases, children grow out of their seizures, and in other cases, people require lifelong treatment. Unfortunately, medications are only effective for just over 50% of people. Many patients experience side effects like dizziness, fatigue, weight gain, memory issues, and depression.
Alternative Treatments for Seizures
Because the current treatments for seizures are only somewhat effective, people are looking to alternative treatments. Examples include the ketogenic diet and herbal approaches, including using CBD products for treating their epilepsy.
What is CBD?
CBD is also known as cannabidiol, and it comes from the cannabis sativa plant. There are different strains of the cannabis plant, including medical marijuana and the industrial hemp plant—which is where the CBD for CBD products comes from.
What makes these plants different from one another is the number of different cannabinoids they contain. The marijuana plant contains high levels of tetrahydrocannabinol (THC), which is a psychoactive cannabinoid, whereas the industrial hemp plant, which CBD products come from, contains very little THC. Furthermore, CBD products are also made with purified cannabidiol, also known as CBD isolate, which does not contain any THC.
Treatment of Seizures with CBD
CBD products have caught the attention of the American people and are becoming more popular every day. Many people report that using CBD helps their pain, anxiety, and sleeping issues, without the side effects of most medications. Clinical trials on using CBD oil for various uses have been very promising.
Researchers are just beginning to explore all of the potential uses of CBD, and there have already been several positive research studies on using CBD for the treatment of seizures.
Approval of Epidolex for the Treatment of Seizures
Epidiolex, a purified, pharmaceutical-grade CBD product has been approved by the U.S. Food and Drug Administration (FDA) for two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome. This approval is the first of its kind in the treatment of any medical condition with a CBD product. Until this point, these two conditions did not have any FDA-approved treatments.
Research on Epidolex shows that it is effective in treatment-resistant seizures of all types in both adults and children. Using this product resulted in improvements in both the severity and frequency of seizures.
The FDA approval not only gives hope to people with this form of epilepsy, it also shows that CBD oil can be an effective treatment for treatment-resistant epilepsy. Therefore, it is a promising option to treat seizures of various types.
Other Studies on CBD and Seizures
The first type of studies that looked at using CBD for seizures were animal studies. They showed that CBD was effective in preventing seizures, potentially through its effect on 5HT1A or 5HT2A receptors.
CBD products have been studied in humans with Dravet syndrome. Clinical trials show that CBD oil significantly reduced the frequency of convulsive seizures with this condition over a 14-week time frame. However, the majority of the participants experienced adverse side effects, including fatigue, dizziness, and sleepwalking. In addition, some individuals experienced elevated liver enzymes.
Cannabidiol has also been shown to be effective (in clinical trials) in the treatment of Lennox-Gastaut syndrome. A recent study found that CBD oil decreased seizure frequency in epilepsy patients and was generally well tolerated. Although many participants in the study experienced some adverse side effects, the majority of them were mild to moderate.
Side Effects of CBD
Although CBD is generally well tolerated, it can cause side effects, including dry mouth, fatigue, and diarrhea. CBD oil may also interact with some medications, including blood thinners, so it should never be used without first consulting your physician.
A Summary of What the Research Says
Research supports the idea that cannabidiol (CBD) oil is an effective anti-seizure medication in animal models and humans.
There have been several clinical trials that demonstrate that CBD may be able to treat treatment-resistant seizures and treat epilepsy effectively.
Where Does the FDA Stand on CBD’s Legality?
While cannabis products containing THC are still illegal in most states, the Farm Bill makes it clear that hemp products containing trace amounts of THC are legal at a federal level in the United States.
As previously mentioned, the FDA has approved the use of Epidiolex for certain types of treatment-resistant seizures. More research is currently being conducted on the medical use of CBD for other conditions.
The increase in scientific investigations is due in part to many testimonies like this one from a veteran, that indicate the medical use of CBD may significantly increase the quality of life for many people without adverse effects.
Final Thoughts on Using CBD for Seizures
There is good evidence to support using CBD for treating seizures. The Epilepsy Center states that “a number of studies have shown the benefit of specific plant-based CBD products in treating specific groups of people with epilepsy who have not responded to traditional therapies.”
Keep in mind that the FDA does not currently regulate CBD products. When purchasing CBD products, choose those that have undergone third-party testing to ensure they meet certain quality and purity standards.
If you are considering using CBD products to treat your seizures, always speak with your doctor first.CBD products may help people with a variety of disorders. Get the facts about using CBD for seizures.
Updated on May 25, 2020. Medical content reviewed by Dr. Joseph Rosado, MD, M.B.A, Chief Medical Officer
Medical marijuana for epilepsy has shown promise as a safe, effective treatment that doesn’t produce the often-severe side effects of traditional medications. Understanding the disorder and how medical cannabis for epilepsy works helps you determine if it is a suitable treatment option for you or a loved one.
Epilepsy Video Transcript:
Epilepsy is a seizure disorder in which there is a sudden temporary change in how the brain functions. The healthy brain is made up of millions of inter-connecting nerve cells called neurons. These cells are constantly communicating with each other by sending signals through tentacle like connections called axons and dendrites. Neurons normally generate impulses up to 80 times a second. During an epileptic seizure that rate can increase up to 500 times a second. Epileptic seizures may result in blackouts, involuntary movement of the arms and legs, and distorted perceptions. When the impulse rate returns to normal, the seizure ends and the patient is generally left with a feeling of extreme fatigue. There are many different forms of epilepsy, and management depends on correct diagnosis. Epilepsy can be a lifelong condition that can result in serious complications. Persons with epilepsy need to be managed and monitored by a physician. Learn more below about how medical marijuana can help treat epilepsy.
Why Marijuana Is Effective in Treating Epilepsy
Medical marijuana is an effective alternative for a laundry list of ailments and conditions, and epilepsy is one of those diseases that is highly responsive to weed. Many patients suffering from epilepsy and other seizure disorders have found great relief from medical marijuana, either taken on its own or in conjunction with other epilepsy medications. Some epileptics who cannot tolerate other anti-seizure medications have been able to use marijuana to successfully control their seizures.
Substances in marijuana called cannabinoids affect cells in the body called cannabinoid receptors. Cannabidiol, or CBD, is one of those substances that may affect the body in a way that helps reduce seizures. Unlike THC, which creates the “high” feeling, CBD does not cause psychoactive effects. This lack of psychoactive effects allows patients to live with fewer seizures without dealing with the high feeling if they prefer to avoid it.
Research on Medical Marijuana and Epilepsy
The subject of using medical marijuana for seizures has been of interest to researchers for some time. Research is often difficult due to legal issues, federal regulations and limited access to cannabidiol, the substance that may help reduce seizures. Marijuana is considered a Schedule 1 substance with no medicinal value at the federal level, which limits the opportunities for research. However, recent research shows the use of the drug to treat epilepsy symptoms has promise.
For example, Scientific American reported on a study involving the use of a cannabis-based drug known as Epidiolex, which is a purified oil extract containing 99 percent cannabidiol, or CBD. This is a chemical found in marijuana that does not produce psychoactive effects. This form of treatment was provided to patients in addition to the existing medications they were using, and all of the patients were aware of what they were taking.
According to the publication, the addition of CBD helped reduce seizures in nearly 37 percent of patients, and two percent of patients reported that they were free of seizures entirely. Although nearly 80 percent of patients participating in the study reported effects such as fatigue, diarrhea and sleepiness, only three percent of them removed themselves due to these events.
Substantial research into the potential benefits of medical marijuana for epilepsy has largely been stymied in the U.S. due to roadblocks erected by the federal government. But Time magazine reported on a potentially groundbreaking clinical trial that could go a long way toward backing the claims of marijuana advocates with unassailable science.
The magazine reported that University of Colorado researchers were involved in studying the genetic makeup of people suffering from a form of epilepsy known as Dravet Syndrome. The researchers were specifically looking for patients who had used Charlotte’s Web, a strain of weed known to have particularly substantial benefits for those suffering from epilepsy.
The purpose of the study was to determine if there are genetic reasons why some patients see positive results from the strain and others see no benefit. One group participating in the study would have seen their seizure activity reduced at least by half after using Charlotte’s Web, while the others would either have seen minimal or no effects.
The Charlotte’s Web strain is high in CBD and low in THC, the psychoactive component of cannabis. The main method of ingestion of the strain is through oil. Several children have been treated in this manner, including one Charlotte Figi, from which the strain takes its name. She was the first epilepsy patient, according to the magazine, who was successfully treated using Charlotte’s Web.
A great deal of anecdotal evidence shows that Charlotte’s Web can be an extremely effective treatment, but federal laws have made it exceedingly difficult to prove it scientifically. But this trial, the magazine reports, can be an important first step toward building a scientific argument.
The study is ongoing, and it is unclear when the results will be known. However, the principal investigator involved in the study said it could eventually allow children suffering from Dravet Syndrome to one day be screened so parents will know whether or not they would benefit from the use of Charlotte’s Web.
A study at Children’s Hospital Colorado reviewed cases of pediatric patients suffering from epilepsy who received treatment using a cannabis extract. Of those patients, 57 percent saw some reduction in seizure activity. Thirty-three percent of those patients had their seizure activity reduced by 50 percent or more.
Two additional studies are taking place at Children’s Hospital Colorado. One study will follow pediatric patients for three years. Blood tests, EEGs and patient diaries will gather data for the study. The second study focuses on the body’s processing of CBD, including the time it takes to kick in and how long it stays in the system. This study could help with dosing guidelines for using cannabis to treat pediatric epilepsy.
A studied concluding in 2017 found that medical marijuana can be beneficial for treating children and adolescents with epilepsy. Dr. Shane Shucheng Wong, MD and Timothy E. Wilens, MD from Massachusetts General Hospital conducted a study that studied the effect of medicinal cannabis in the adolescent treatment of epilepsy and chemotherapy-induced nausea that included randomized controlled trials, case reports, retrospective chart reviews, and open-label trials. They found that cannabinoids far out-performed other drugs in reducing in the frequency of seizures.
Treating Epilepsy With Marijuana
Marijuana helps many patients with epilepsy control the seizure symptoms related to the disorder. Those specific symptoms depend on the type of seizures the patient experiences and how those seizures typically present themselves in the patient. Just as the symptoms of epilepsy vary from one patient to the next, the specific strains that prove effective may vary. Some patients may respond very well to a particular strain, while others receive little to no relief from the same strain.
The primary strains are indica and sativa, with hybrid strains available that emphasize particular traits from the other two types. Indica strains generally contain more CBD than THC, which makes them popular for treating epilepsy. Indica also tends to create a sedative or relaxing effect, which can help treat other medical issues, such as anxiety, headaches, chronic pain, sleeping disorders, and muscle spasms. Kush, White Widow, and Northern Lights are three examples of indica.
Sativa tends to have an uplifting, energizing effect, which can be good for daytime, but it may interfere with sleep at night. While it does not contain as much CBD, some people do find relief from spasms and seizures from sativa. It can also help with nausea and stimulate the appetite if you suffer from those issues.
The best strains of marijuana for treating epilepsy tend to include those that are high in CBD and low in THC. This provides the seizure-reducing effects of CBD without the psychoactive side effects. Charlotte’s Web fits that profile well and is an effective option for many patients suffering from epilepsy. A similar product called Haleigh’s Hope is now on the market in Colorado with a focus on treating kids with epilepsy.
While some people seem to respond well to CBD, strains that include some THC with CBD may prove effective when CBD alone doesn’t reduce seizures. Some researchers believe the two substances work together creating an entourage effect. A marijuana doctor can evaluate your medical needs to determine which strain of marijuana is best for your particular situation.
Medical marijuana is available in a number of different administration methods. Smoking is often associated with marijuana. This method produces almost immediate effects, which is why it is a popular option for adults. Some people worry about the effects on the respiratory system when smoking marijuana, which is why some other methods are growing in popularity for medical marijuana. Smoking is also not an option for children who suffer from epilepsy.
Vaporization is one of those alternative methods. A vaporizer uses a lower temperature, which reduces byproducts created during the process. The chemicals in the marijuana enter the bloodstream quickly for fast relief similar to smoking.
Oils and tinctures use concentrations of marijuana, which you can add to food or drinks, or you can take the oil alone. One option is to add the oil to a capsule to swallow, similar to any medication in pill form. These methods typically provide quick relief. The advantage of using cannabis oil for epilepsy is the control over dosing. This is particularly important with high CBD levels. With quality oil that is properly prepared, the dosing can be very accurate for an effective treatment.
Edibles are also an option for ingesting cannabis without smoking or vaping it. You can find a wide range of food products infused with cannabis for an easy way to get the beneficial effects. Some of the options include cookies, ice cream, lollipops, and gum. When you consume edibles, the effects generally last longer than they do with smoking or vaping, but they take longer to initially take effect. Edibles can take anywhere from 30 minutes to a few hours to start working.
Children with epilepsy most commonly take cannabis products in liquid form instead of smoking it in the traditional recreational manner. These products are sometimes available in gels or patches as well. The high levels of CBD in these products help control the seizure activity while minimizing the “high” sensation. Most of these products have some THC, but they are usually limited.
Potential Side Effects
Medical marijuana is very effective in controlling epileptic seizures without the side effects found in traditional medicines used to treat epilepsy. The side effects associated with cannabis are typically mild and are classified as “low risk,” with euphoric mood changes among the most frequent side effects.
Some people report the following with the use of weed to treat epilepsy:
Those side effects typically go away, and in some cases, those side effects are considered positives. For instance, someone who has epilepsy and also has trouble sleeping appreciates the sleepiness it causes. A patient with epilepsy who needs to gain weight or has a low appetite benefits from the increased appetite from cannabis.
Most medical marijuana states allow the use of medical marijuana for epilepsy and seizures. If you are looking for relief from epilepsy or any other seizure disorder, we can help. We can connect you with hundreds of quality marijuana doctors across the country in all legal marijuana states and ensure you are in compliance with your state laws. Book an appointment today and let us help improve your quality of life!
Additional Epilepsy & Cannabis Resources
For more information about how cannabis can be used to treat Epilepsy, check out our resources:
What Is Epilepsy?
Epilepsy is a disorder of the central nervous system characterized by loss of consciousness and convulsions. The seizures caused by epilepsy are due to issues in the brain rather than temporary medical conditions, such as a high fever. Approximately 1 of every 26 Americans will have a seizure disorder at some point in life. Estimates show approximately three million Americans have epilepsy right now. Each year, another 200,000 people receive an epilepsy diagnosis.
The disorder produces intense, abnormal electrical activity in the brain, which can cause seizures. This disorder can be caused by brain damage, a tumor or an infection, but in most cases, the cause is unknown. Environmental toxins and metabolic disturbances may also be to blame for some cases.
Seizures vary significantly in how they manifest physically, how long they last and how severe they are. Small, minor seizures may last only a short period. These types of seizures don’t cause brain damage. More severe seizures can cause major convulsions lasting an extended period. Severe seizures may injure the brain permanently.
Seizures fall into one of two categories: focal or generalized. Simple or partial focal seizures happen when the abnormal brain activity occurs in only one area of the brain. Patients remain conscious during simple partial seizures, and they experience no impairment to memory or cognitive abilities. They may experience jerking, sensory symptoms, temporary paralysis, changes in vision, difficulty making simple movements or changes in mood. This type of seizure affects less than 15 percent of people diagnosed with epilepsy.
Complex or dyscognitive partial seizures result in loss or change in your consciousness. This might include confusion, memory loss and loss of awareness. Some people perform repeated movements during the seizure, such as walking in circles or rubbing their hands together. To other people, a complex partial seizure may cause the patient to look dazed or out of it. Dyscognitive partial seizures affect more than one-third of people with epilepsy. Because they don’t always cause symptoms associated with seizures, focal seizure symptoms may be mistaken for migraines or other disorders.
Generalized seizures happen when the disruption affects the entire brain. Generalized seizures affect more than 30 percent of people dealing with epilepsy. The six types of generalized seizures include:
- Absence — previously called petit mal seizures: These seizures are common in children, and they often cause staring or small body movements as well as a brief period of unawareness of the surroundings.
- Tonic: Muscle stiffening characterizes tonic seizures. The stiffening particularly affects the legs, arms, and back, which may cause falls or mobility issues.
- Atonic: This type results in loss of muscle control. These seizures may cause you to fall or collapse suddenly, contributing to the nickname “drop” seizure.
- Clonic: These seizures cause a repeated jerking of the muscles, usually in the neck, face, and arms.
- Myoclonic: Sudden, quick muscle jerks or twitches often occur during myoclonic seizures. They usually affect the arms and legs.
- Tonic-clonic — previously called grand mal seizures: The most severe symptoms typically occur with this type of seizure. They often cause a loss of consciousness, stiffening and shaking. Loss of bladder control and tongue biting may also occur during the seizure.
The symptoms of epilepsy vary from one person to the next and depend on the type of seizures you have. While your seizure symptoms may not be the same as someone else, your specific symptoms tend to be the same each time with a repeated pattern during episodes.
Potential symptoms of epilepsy include:
- Staring into space for an extended period
- Loss of consciousness
- Uncontrollable jerking in the extremities
- Loss of muscle tone
- Abdominal discomfort
- Mood changes
- Tingling or dizziness
- Flashing lights
- Changes in your senses, including how things look, smell, taste, sound or feel
- Repetitive movements
- Impaired speech
Epilepsy can cause problems beyond the immediate physical symptoms patients experience. The disorder tends to disrupt life due to the potential for seizures at any time. Some patients aren’t able to drive or engage in other normal activities. Even something as simple as bathing can become dangerous. People with epilepsy are 15 to 19 times more likely to drown than people without the disorder. This can happen while swimming or while bathing.
Potential complications related to epilepsy include:
- Car accidents
- Falls with the potential for head injuries and broken bones
- Complications during pregnancy with potential danger to both the baby and the mother
- Depression, anxiety and other psychological problems
Some rare complications can cause life-threatening situations for people with epilepsy. Status epilepticus describes continuous seizures that last more than five minutes. This condition also applies to recurrent seizures that occur without regaining consciousness between them. This condition increases your risk for death and permanent brain damage.
Another rare complication is called sudden unexplained death in epilepsy (SUDEP). The risk is low, but some patients with epilepsy suffer sudden unexplained death. Heart or respiratory issues could be to blame, although the specific cause for SUDEP is unknown.
Children and adults over the age of 60 have the highest rates of epilepsy diagnosis. In some cases, people who experience dementia also develop epilepsy. People closely related to someone with epilepsy have an increased risk of developing epilepsy.
Doctors perform a number of tests to diagnose epilepsy. Some of those tests, such as blood tests, are used to rule out other possible causes for your symptoms. An electroencephalogram (EEG) is commonly used to diagnose the condition. Electrodes attached to the scalp record your brain’s electrical activity to look for unusual patterns. In some cases, your doctor may use a CT scan or MRI to get a closer look at the brain to identify potential cause of the seizures or abnormalities in the brain. A PET scan may help your doctor look at the electrical activity in your brain.
Current Treatments for Epilepsy
Once diagnosed with epilepsy, patients typically seek treatment to help control the seizures and other symptoms. Some children may outgrow epilepsy, while others need to continue seeking treatment to control the symptoms for life. Treatment is necessary even when seizures aren’t severe. Even a mild seizure can have serious side effects if it occurs during certain activities, such as driving, so it’s important to keep the seizures under control for the safety of the patient and those around the patient.
Medication is the most common current treatment for epilepsy. Some people diagnosed with epilepsy undergo surgery to control the condition, although this option is less common. These treatments help control seizures in about 80 percent of patients according to Mayo Clinic, but the remaining 20 percent go without relief from traditional epilepsy treatments.
Treating epilepsy can be difficult because each case is unique. The seizures and symptoms vary from patient to patient. Epileptic seizures are often controlled through drug therapy drugs such as anticonvulsants. Some patients with epilepsy must take several different drugs to create a combination that controls seizures effectively.
Traditional epileptic medications come with side effects such as:
- Slurring of speech
- Double vision
- Weight gain
- Hyperactivity in children
- Sleep disturbances
- Gum dysplasia
- Changes in mood
- Bone density loss
- Skin rashes
- Memory problems
This means the 80 percent of patients successfully treated with traditional methods still have to deal with negative side effects that are difficult to handle.Learn more about how medical marijuana can help treat Epilepsy at Marijuana Doctors. Find treatment options and reviews on local marijuana doctors in your area today! ]]>